PHARMACOKINETICS, PHARMACODYNAMICS AND SAFETY OF 15 MG-TOLVAPTAN ADMINISTERED ORALLY FOR 7 CONSECUTIVE DAYS TO CHINESE PATIENTS WITH CHILD-PUGH B CIRRHOSIS

Background: Tolvaptan, a selective vasopressin V2-receptor antagonist, can elicit a diuretic effect without significant electrolyte loss.The aims were to evaluate multiple-dose pharmacokinetics, pharmacodynamics and safety of daily administration of 15 mg tolvaptan in Chinese adult patients with confirmed Child-Pugh Class B cirrhosis accompanied by

Fresnel incoherent correlation holography (FINCH) is a self-interference based super-resolution three-dimensional imaging technique.FINCH in inline configuration requires an active phase modulator to record at least three phase-shifted camera shots to reconstruct objects without twin image Cable Saver and bias terms.In this study, FINCH is realized

Diabetic foot ulcers (DFUs) are associated with a high risk of amputations and a 50% 5-year survival rate due at least in part to the limited angiogenic and wound healing capacity of patients with diabetes.Cell therapy via intramuscular injection of peripheral blood mononuclear cells showed encouraging but limited results.Such limitations may arise

Objectives This review aimed to synthesise evidence on (1) the prevalence of common mental health disorders (MHDs) in Cameroon; (2) the effectiveness of mental health management interventions; (3) the risk factors for common MHDs in Cameroon and (4) map the state of research on common mental disorders in Cameroon.Design A systematic review.Data sou